CHO-CTLA4

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The CHO-CTLA4 cell line is a stable recombinant CHO (Chinese Hamster Ovary) cell line engineered to express the CTLA4 receptor at a medium-low level, approximately 3,000 molecules per cell. This cell line was created using an innovative landing pad technology that facilitates the targeted integration of the CTLA4 gene at a specific, pre-validated genomic locus. CTLA4, also known as CD152, is a critical immune checkpoint protein found primarily on T-cells. It functions by competing with CD28 for binding to B7 molecules (CD80 and CD86) on antigen-presenting cells, leading to the downregulation of T cell activation. This mechanism is vital for maintaining immune self-tolerance and preventing autoimmunity. CTLA4's role in modulating immune responses has made it a significant target in cancer immunotherapy, particularly in immune checkpoint blockade strategies.
The expression of CXCR7 in this cell line was confirmed using flow cytometry.