B-LCL-HROC285

B-LCL-HROC285 is an Epstein-Barr virus (EBV) transformed B lymphocyte cell line derived from a patient, who had colon adenocarcinoma associated with Lynch syndrome. This specific type of colon cancer is linked to hereditary non-polyposis colorectal cancer (HNPCC), commonly caused by mutations in DNA mismatch repair genes. The B-LCL-HROC285 cell line allows for the study of EBV-related transformation processes in B cells, as well as insights into cancer-related immune responses.
The B-LCL-HROC285, provides a valuable tool for understanding the immune system's interactions with cancer cells, particularly how transformed B cells might interact with the immune environment in colorectal cancers arising from Lynch syndrome. This cell line is useful for immunological and oncological studies due to its genetic background and the EBV transformation process, which is known to influence B-cell proliferation and clonal selection.