CHO-FOLR1

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The CHO-FOLR1 cell line is a stable recombinant CHO (Chinese Hamster Ovary) cell line engineered to express the FOLR1 receptor at a medium-high level, approximately 15,000 molecules per cell. This cell line was developed using advanced landing pad technology, which ensures precise and reproducible integration of the FOLR1 gene at a specific, pre-validated genomic locus. FOLR1, also known as Folate Receptor Alpha (FRα) or FBP, is a GPI-anchored membrane protein with high affinity for folate, facilitating its transport into cells. FOLR1 is significantly overexpressed in various epithelial cancers, including ovarian, breast, and non-small cell lung cancers, making it a valuable target for cancer immunotherapies, including CAR T cell therapies and bispecific antibodies.
The expression of FOLR1 in this cell line was confirmed using flow cytometry with a target-specific antibody, ensuring reliable and consistent receptor density across the cell population.