CHO-TACD2

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The CHO-TACD2 cell line is a stable recombinant CHO (Chinese Hamster Ovary) cell line engineered to express the TACD2 receptor at a medium-high level, approximately 12,600 molecules per cell. This cell line was developed using an innovative landing pad technology, ensuring precise and reproducible integration of the TACD2 gene at a specific, pre-validated genomic locus. TACD2, also known as TROP2 or GA733-1, is a tumor-associated calcium signal transducer. It plays a critical role in intracellular calcium signaling, which is crucial for various cellular processes, including growth, division, and differentiation. Overexpression of TACD2 has been observed in various carcinomas, such as colorectal, gastric, and pancreatic cancers, making it a potential target for antibody-drug conjugates and immunotherapy.
The expression of CXCR7 in this cell line was confirmed using flow cytometry.