HEK293-CCR8

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The HEK293-CCR8 cell line is a stable recombinant HEK293 cell line engineered to express the CCR8 receptor at a medium-high level, approximately 22,000 molecules per cell. This cell line was developed using inscreenex's landing pad technology, ensuring precise and reproducible integration of the CCR8 gene at a specific, pre-validated genomic locus. CCR8, also known as CHEMR1 or CDw198, is a G protein-coupled receptor (GPCR) that is predominantly expressed on regulatory T cells (Tregs). It plays a crucial role in the suppression of immune responses within the tumor microenvironment, aiding tumor cells in evading immune detection. Due to its role in maintaining an immunosuppressive environment, CCR8 has become a promising target for novel cancer immunotherapies aimed at enhancing anti-tumor immunity by reducing Treg-mediated suppression.The expression of CCR8 in this cell line was confirmed using flow cytometry with a target-specific antibody, ensuring consistent and reliable receptor density across the cell population.