HEK293-CXCR4

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The HEK293-CXCR4 cell line is a stable recombinant HEK293 cell line engineered to express the CXCR4 receptor at a medium-high level, approximately 7,800 molecules per cell. This cell line was developed using inscreenex's landing pad technology, which ensures precise and reproducible integration of the CXCR4 gene at a specific, pre-validated genomic locus. CXCR4, also known as CD184, is a chemokine receptor belonging to the G protein-coupled receptor (GPCR) family. It plays a crucial role in immune cell trafficking, hematopoiesis, and serves as a co-receptor for HIV entry into cells. CXCR4 is also implicated in tumor growth, metastasis, and angiogenesis, particularly in hematological malignancies, making it a significant target in cancer research and therapy development.
The expression of CXCR4 in this cell line was confirmed using flow cytometry with a target-specific antibody, ensuring consistent and reliable receptor density across the cell population.