HEK293-TACD2

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The HEK293-TACD2 cell line is a stable recombinant HEK293 cell line engineered to express the TACD2 receptor at a medium-high level, approximately 10,000 molecules per cell. This cell line was developed using inscreenex's landing pad technology, which ensures precise and reproducible integration of the TACD2 gene at a specific, pre-validated genomic locus. TACD2, also known as TROP2 or GA733-1, is a tumor-associated calcium signal transducer that plays a key role in intracellular calcium signaling, crucial for cellular processes such as growth, division, and differentiation. Overexpression of TACD2 has been observed in various carcinomas, including colorectal, gastric, and pancreatic cancers, making it a significant target for antibody-drug conjugates and immunotherapy.The expression of TACD2 in this cell line was confirmed using flow cytometry with a target-specific antibody, ensuring reliable and consistent receptor density across the cell population.